Description
Product Characteristics: 1 phosphatidylinositol 3 phosphate 5 kinase antibody, 1 phosphatidylinositol 4 phosphate 5 kinase antibody, 1-phosphatidylinositol 3-phosphate 5-kinase antibody, CFD antibody, epididymis luminal protein 37 antibody, FAB1 antibody, FAB1, S. cerevisiae, homolog of antibody, FYV1_HUMAN antibody, FYVE finger containing phosphoinositide kinase antibody, FYVE finger-containing phosphoinositide kinase antibody, KIAA0981 antibody, MGC40423 antibody, p235 antibody, Phosphatidylinositol 3 phosphate 5 kinase type III antibody, Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III antibody, Phosphatidylinositol 3-phosphate 5-kinase antibody, Phosphatidylinositol 3-phosphate 5-kinase type III antibody, Phosphatidylinositol 4 phosphate 5 kinase type III antibody, Phosphoinositide kinase, FYVE finger containing antibody, PIKfyve antibody, PIP5K antibody, PIP5K3 antibody, PIPkin III antibody, PIPkin-III antibody, PtdIns(4)P 5 kinase antibody, Type III PIP kinase antibody, ZFYVE29 antibody, Zinc finger, FYVE domain containing 29 antibody
Target Information: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\, also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\, an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]